The film tells about the first difficult years of saint Frances Xavier Cabrini’s mission with Italian immigrants in the USA at the end of the 19th century. After accepting the mission entrusted to her by the Pope, and renouncing her lifelong dream of going to China, she arrives in New York with 6 of her young nuns, but here nothing she believed she would find is ready: neither a house, nor the school, nor the orphanage. Moreover, the Archbishop of New York wants to send her back to Italy. Frances and her nuns witness the miserable conditions of Italian immigrants considered the bottom of American society. Overcoming many obstacles she starts a school in Little Italy and a small orphanage. Her strong character supported by a lively intelligence and an unshakable faith, even in the face of the hardest challenges, help her carry out a concrete and effective mission, including the foundation of the Columbus Hospital in New York. She is the first American Saint and Patron Saint of Migrants.